Peptide data sheet
SS-31
Longevity · Elamipretide · MTP-131 · Bendavia
Verdict
promisingfor mitochondrial function in early-stage human research
By MrPepTalks Editorial
Reviewed for scientific accuracy · research information, not medical advice
Last updated Reviewed
Quick answer
SS-31 (elamipretide) is a small, mitochondria-targeting research peptide. It is commonly researched for mitochondrial function and cellular energy, and people report interest in recovery and longevity uses. Human evidence is still early, side effects are not fully characterized, and it is not FDA-approved for human use.
- Class
- Mitochondria-targeting tetrapeptide (Szeto-Schiller peptide)
- Half-life
- Short; commonly reported in hours in early studies
- FDA status
- Not FDA-approved; investigational, studied in clinical trials
Which form actually works?
Injectable (subcutaneous, research)
Promising
Most human trials of elamipretide have looked at an injectable form. The signal is early-stage and mixed across conditions; think promising-but-unproven, not settled.
Topical / other routes
Unproven
Non-injectable routes show up in marketing more than in trials. There is little controlled human data here, so treat any topical claims as unproven.
Third-Party Testing & Certificate of Analysis (COA)
A certificate of analysis (COA) is a lab document that reports what a specific batch of material actually contains. Reputable research suppliers publish one for every batch, tied to a lot number you can match against the vial you received.
- HPLC — purity
- High-performance liquid chromatography reports purity as a percentage: how much of the sample is the intended compound rather than impurities.
- Mass spectrometry (MS) — identity
- Mass spectrometry confirms identity by measuring the sample's molecular mass, so it matches the peptide the label names.
It also matters who ran the test. In-house results come from the seller's own lab; an independent third-party lab has no stake in the result, so its COA generally carries more weight. Look for a named testing laboratory, a batch or lot number, and a test date that lines up with the vial in hand.
New to reading one? This guide walks through a COA line by line: how to read a peptide COA.
Sources
- Szeto HH. First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics. Br J Pharmacol. 2014;171(8):2029-2050.
- Karaa A, et al. Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy. Neurology. 2018;90(14):e1212-e1221.
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