Peptide data sheet
MOTS-c
Longevity · MOTS-c · MOTSc
Verdict
unprovenfor metabolic and exercise-related research in people
By MrPepTalks Editorial
Reviewed for scientific accuracy · research information, not medical advice
Last updated Reviewed
Quick answer
MOTS-c is a 16-amino-acid peptide encoded inside mitochondrial DNA. In lab and animal research it has been studied for how cells handle glucose and energy, and it is often described as an exercise-mimetic candidate. Controlled human trials are essentially absent, so what it does in people is still an open question. It is sold for research use only and is not FDA-approved.
- Class
- Mitochondrial-derived peptide (MDP)
- Half-life
- Short in circulation; not well characterized in humans
- FDA status
- Not FDA-approved; sold for research use only
Which form actually works?
Lyophilized research vial
Unproven
The form Circle Peptides and most research suppliers sell. Studied in laboratory settings; there is no established human protocol, and reported experiences from the research community are anecdotes, not evidence.
Third-Party Testing & Certificate of Analysis (COA)
A certificate of analysis (COA) is a lab document that reports what a specific batch of material actually contains. Reputable research suppliers publish one for every batch, tied to a lot number you can match against the vial you received.
- HPLC — purity
- High-performance liquid chromatography reports purity as a percentage: how much of the sample is the intended compound rather than impurities.
- Mass spectrometry (MS) — identity
- Mass spectrometry confirms identity by measuring the sample's molecular mass, so it matches the peptide the label names.
It also matters who ran the test. In-house results come from the seller's own lab; an independent third-party lab has no stake in the result, so its COA generally carries more weight. Look for a named testing laboratory, a batch or lot number, and a test date that lines up with the vial in hand.
New to reading one? This guide walks through a COA line by line: how to read a peptide COA.
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