Peptide data sheet
5-Amino-1MQ
Longevity · 5-amino-1-methylquinolinium · 5A1MQ
Verdict
unprovenThe unproven label reflects an evidence base that is almost entirely animal and cell models. The mechanism is real and interesting, but controlled human data is not there yet, so nothing here should be read as settled.
By MrPepTalks Editorial
Reviewed for scientific accuracy · research information, not medical advice
Last updated Reviewed
Quick answer
5-Amino-1MQ (5-amino-1-methylquinolinium, CAS 685079-15-6) is a small-molecule NNMT enzyme inhibitor studied in the lab, not a peptide. It is not FDA-approved. It is most commonly researched for metabolism, body composition and cellular energy signaling, mainly in animal and cell models. Effects in humans are still being studied, so what people report online remains anecdote rather than proof.
- Class
- Small-molecule NNMT enzyme inhibitor (research compound)
- Half-life
- Not characterized in humans; no human pharmacokinetic study has been published
- FDA status
- Not FDA-approved; sold for laboratory and research use only
Which form actually works?
Oral (research form)
Unproven
The oral research form is the one most people talk about online because it is convenient. How much actually reaches the bloodstream this way is not well established, so the honest label here is unproven in humans.
Injectable (research form)
Unproven
An injectable research form also circulates. Controlled human data comparing routes does not exist yet, so treat any route-versus-route claims as unsettled rather than answered.
Third-Party Testing & Certificate of Analysis (COA)
A certificate of analysis (COA) is a lab document that reports what a specific batch of material actually contains. Reputable research suppliers publish one for every batch, tied to a lot number you can match against the vial you received.
- HPLC — purity
- High-performance liquid chromatography reports purity as a percentage: how much of the sample is the intended compound rather than impurities.
- Mass spectrometry (MS) — identity
- Mass spectrometry confirms identity by measuring the sample's molecular mass, so it matches the peptide the label names.
It also matters who ran the test. In-house results come from the seller's own lab; an independent third-party lab has no stake in the result, so its COA generally carries more weight. Look for a named testing laboratory, a batch or lot number, and a test date that lines up with the vial in hand.
New to reading one? This guide walks through a COA line by line: how to read a peptide COA.
Sources
- Neelakantan H et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochem Pharmacol, 2018.
- Kraus D et al. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature, 2014.
- Sun WD et al. Nicotinamide N-methyltransferase (NNMT): a novel therapeutic target for metabolic syndrome. Front Pharmacol, 2024.
- PubChem Compound Summary CID 950107 (5-amino-1-methylquinolinium). National Center for Biotechnology Information. Retrieved 2026-07-26.
- PubChem Compound Summary CID 66522933 (5-amino-1-methylquinolinium iodide). National Center for Biotechnology Information. Retrieved 2026-07-26.
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