Peptide data sheet
Pinealon
Cognitive · EDR · Glu-Asp-Arg
Verdict
unproventhin, largely single-group evidence
By MrPepTalks Editorial
Reviewed for scientific accuracy · research information, not medical advice
Last updated Reviewed
Quick answer
Pinealon is a synthetic tripeptide, Glu-Asp-Arg, also written EDR. It came out of a Saint Petersburg gerontology institute and is sold as a research peptide. Published work is mostly cell-culture and rodent experiments, much of it from that same institute, plus a few small Russian-language human reports. No studies are registered on ClinicalTrials.gov.
- Class
- Short peptide bioregulator (cytogen)
- Half-life
- Not established in published human data
- FDA status
- Not approved by the FDA; sold for laboratory research use only
Third-Party Testing & Certificate of Analysis (COA)
A certificate of analysis (COA) is a lab document that reports what a specific batch of material actually contains. Reputable research suppliers publish one for every batch, tied to a lot number you can match against the vial you received.
- HPLC — purity
- High-performance liquid chromatography reports purity as a percentage: how much of the sample is the intended compound rather than impurities.
- Mass spectrometry (MS) — identity
- Mass spectrometry confirms identity by measuring the sample's molecular mass, so it matches the peptide the label names.
It also matters who ran the test. In-house results come from the seller's own lab; an independent third-party lab has no stake in the result, so its COA generally carries more weight. Look for a named testing laboratory, a batch or lot number, and a test date that lines up with the vial in hand.
New to reading one? This guide walks through a COA line by line: how to read a peptide COA.
Sources
- PubChem CID 10273502, Glu-Asp-Arg (pinealon): molecular formula, molecular weight, IUPAC name, SMILES, InChIKey and synonyms.
- PubMed search for "pinealon": the whole indexed literature (22 records at time of writing).
- ClinicalTrials.gov search for "pinealon": no registered studies.
- Khavinson V, Ribakova Y, Kulebiakin K, et al. Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes. Rejuvenation Res. 2011;14(5):535-41. PMID 21978084.
- Fedoreyeva LI, Kireev II, Khavinson VKh, Vanyushin BF. Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA. Biochemistry (Mosc). 2011;76(11):1210-9. PMID 22117547.
- Silanteva IA, Komolkin AV, Morozova EA, et al. Role of Mono- and Divalent Ions in Peptide Glu-Asp-Arg-DNA Interaction. J Phys Chem B. 2019;123(9):1896-1902. PMID 30762356.
- Khavinson VKh, Lin'kova NS, Tarnovskaya SI, et al. Short peptides stimulate serotonin expression in cells of brain cortex. Bull Exp Biol Med. 2014;157(1):77-80. PMID 24909721.
- Arutjunyan A, Kozina L, Stvolinskiy S, et al. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia. Int J Clin Exp Med. 2012;5(2):179-85. PMC3342713.
- Khavinson V, Linkova N, Kozhevnikova E, Trofimova S. EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's Disease. Molecules. 2020;26(1):159. PMC7795577.
- Meshchaninov VN, Tkachenko EL, Zharkov SV, et al. [Effect of synthetic peptides on aging of patients with chronic polymorbidity and organic brain syndrome of the central nervous system in remission]. Adv Gerontol. 2015;28(1):62-7. Russian-language; reports a prooxidant signal and reduced CD34-positive cells. PMID 26390612.
- Bashkireva AS, Artamonova VG. [The peptide correction of neurotic disorders among professional truck-drivers]. Adv Gerontol. 2012;25(4):718-28. Russian-language occupational-health study using pinealon and vezugen. PMID 23734521.
- WADA 2026 Prohibited List (valid 1 January 2026). Pinealon is not named; the S0 non-approved-substances class is a catch-all.