Peptide data sheet
Selank
Cognitive · TP-7
Verdict
promisingThe promising label reflects genuine but geographically narrow human data: small clinical studies out of Russia reported an anxiety-reducing signal, and the mechanism has real research behind it, but the trials are small, mostly unreplicated outside Russia, and no large Western RCT has confirmed the effect.
By MrPepTalks Editorial
Reviewed for scientific accuracy · research information, not medical advice
Last updated Reviewed
Quick answer
Selank is a synthetic peptide derived from the immune fragment tuftsin, developed in Russia as an anxiolytic. It is commonly researched for anxiety, focus, and stress resilience, and early human studies reported an anxiety-reducing signal comparable to a common benzodiazepine but without the sedation in those small trials. The catch: the data is thin and mostly regional, it is not FDA-approved, and it is sold for research use only.
- Class
- Synthetic heptapeptide; tuftsin analog (anxiolytic / nootropic research peptide)
- Half-life
- very short in blood (minutes, reported); effects reported to outlast plasma levels
- FDA status
- Not FDA-approved. Registered and used clinically only in Russia; in the United States it is not approved for any use and is sold for laboratory research use only.
- WADA banned?
- No
Which form actually works?
Intranasal (nasal drops / mist)
Promising
The form used in the Russian clinical research and the one most people ask about, because a nasal route is thought to help a fragile peptide reach the brain. This is where the anxiety-reduction signal was reported, and where reported effects such as a subtle calm-focus are described. The evidence is real but small and mostly regional.
Injectable (subcutaneous)
Unproven
Sometimes sold and discussed for research, but the human anxiety data rests on the nasal form, so the injectable route carries less of the studied evidence behind it. Treat claims about it as less supported than the nasal literature, not more.
Third-Party Testing & Certificate of Analysis (COA)
A certificate of analysis (COA) is a lab document that reports what a specific batch of material actually contains. Reputable research suppliers publish one for every batch, tied to a lot number you can match against the vial you received.
- HPLC — purity
- High-performance liquid chromatography reports purity as a percentage: how much of the sample is the intended compound rather than impurities.
- Mass spectrometry (MS) — identity
- Mass spectrometry confirms identity by measuring the sample's molecular mass, so it matches the peptide the label names.
It also matters who ran the test. In-house results come from the seller's own lab; an independent third-party lab has no stake in the result, so its COA generally carries more weight. Look for a named testing laboratory, a batch or lot number, and a test date that lines up with the vial in hand.
New to reading one? This guide walks through a COA line by line: how to read a peptide COA.
Sources
- Zozulya AA, Neznamov GG, Siuniakov TS, et al. Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia. Zh Nevrol Psikhiatr Im S S Korsakova, 2008;108(4):38-48.
- Kolomin T, Morozova M, Volkova A, et al. The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action. Mol Immunol, 2014;58(1):50-55.
- Inozemtseva LS, Karpenko EA, Dolotov OV, et al. Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo. Dokl Biol Sci, 2008;421:241-243.
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