Peptide data sheet
Epitalon
Longevity · Epithalon · Epithalone · Epitalon tetrapeptide · Ala-Glu-Asp-Gly
Verdict
unprovenThe unproven label reflects a real but thin and largely single-region evidence base: laboratory and small early human studies from a handful of Russian groups report effects on aging markers, but independent, blinded, long-term human trials that would establish a benefit do not exist.
Quick answer
Epitalon (epithalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) modeled on a pineal-gland extract. It is commonly researched for telomere biology and markers of aging, and people report interest in it for longevity. Laboratory and small early human studies suggest effects on aging markers, but independent long-term human trials are lacking. It is not FDA-approved and is sold for research use only.
- Class
- Synthetic pineal tetrapeptide (Ala-Glu-Asp-Gly); a synthetic analog of the pineal extract epithalamin
- Half-life
- very short — reported in minutes for small peptides of this size
- FDA status
- Not FDA-approved. Never approved for any use; studied mainly outside large regulated trials and sold for laboratory research use only.
- WADA banned?
- No
Which form actually works?
Injectable (subcutaneous)
Unproven
The form used in most of the early human research from Russian groups. This is where the aging-marker observations were reported, and also where the thinness of the independent evidence base shows up most clearly.
Intranasal / oral
Unproven
Routes people still ask about because they avoid needles. They carry even less human research than the injectable path; how much intact peptide reaches its target by these routes is itself an open question.