Peptide data sheet
PT-141
Sexual health · Bremelanotide · PT141
Verdict
promisingThe promising label reflects the human trial data behind the branded drug for one narrow use; research-grade PT-141 sold for lab use is not the same product and has a thinner safety picture.
By MrPepTalks Editorial
Reviewed for scientific accuracy · research information, not medical advice
Last updated Reviewed
Quick answer
PT-141 (bremelanotide) is a melanocortin-receptor peptide commonly researched for sexual arousal and desire. Unlike most research peptides it has real human trial data: that data supported the branded prescription drug Vyleesi, FDA-approved for one narrow use. Research-grade PT-141 sold for lab use is not that product and is not FDA-approved.
- Class
- Melanocortin receptor agonist (cyclic heptapeptide)
- Half-life
- roughly 2 to 3 hours (reported)
- FDA status
- Vyleesi (bremelanotide) is FDA-approved for one narrow use (premenopausal HSDD). Research-grade PT-141 sold for lab use is a different product intended for laboratory research only.
- WADA banned?
- No
Which form actually works?
Injectable (subcutaneous)
Promising
The form the human trials and the branded prescription drug used. People report the effect timing and the reported side effects here; it also carries the most research context of any form.
Intranasal
Unproven
An earlier research direction that people still ask about. It carries less consistent human data than the injectable path, and blood-pressure signals were part of why that direction was set aside.
Third-Party Testing & Certificate of Analysis (COA)
A certificate of analysis (COA) is a lab document that reports what a specific batch of material actually contains. Reputable research suppliers publish one for every batch, tied to a lot number you can match against the vial you received.
- HPLC — purity
- High-performance liquid chromatography reports purity as a percentage: how much of the sample is the intended compound rather than impurities.
- Mass spectrometry (MS) — identity
- Mass spectrometry confirms identity by measuring the sample's molecular mass, so it matches the peptide the label names.
It also matters who ran the test. In-house results come from the seller's own lab; an independent third-party lab has no stake in the result, so its COA generally carries more weight. Look for a named testing laboratory, a batch or lot number, and a test date that lines up with the vial in hand.
New to reading one? This guide walks through a COA line by line: how to read a peptide COA.
Sources
- Kingsberg SA et al. Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder: Two Randomized Phase 3 Trials (RECONNECT). Obstet Gynecol 2019.
- Simon JA et al. Long-Term Safety and Efficacy of Bremelanotide for Hypoactive Sexual Desire Disorder. Obstet Gynecol 2019.
- Bremelanotide (Vyleesi) — approved by the FDA in 2019 for premenopausal women with hypoactive sexual desire disorder. LiverTox, NIH National Library of Medicine.
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