Peptide data sheet
MK-677
Performance · Ibutamoren · Ibutamoren mesylate · MK-0677
Verdict
unprovenThe unproven label reflects a real but narrow evidence base: MK-677 reliably raises growth-hormone and IGF-1 markers in human studies, but the downstream benefits people want are not established, and safety signals in older and frail populations are a genuine open question.
Quick answer
MK-677 (ibutamoren) is an orally active growth-hormone secretagogue that acts as a ghrelin-receptor agonist. It is commonly researched for raising growth hormone and IGF-1 and, downstream, for appetite, body composition, and sleep. Human studies confirm it elevates those hormone markers, but the real-world benefits people hope for are not established. It is not FDA-approved and is sold for research use only.
- Class
- Growth-hormone secretagogue / ghrelin (GHS-R) receptor agonist (non-peptide small molecule)
- Half-life
- roughly 4 to 6 hours (reported)
- FDA status
- Not FDA-approved. Investigated in clinical trials but never approved for any use; sold for laboratory research use only.
- WADA banned?
- Yes
Which form actually works?
Oral (capsule / liquid)
Unproven
The form used in nearly all the human research and the one people ask about most. Its selling point is that it is orally active, unlike most injectable research peptides. This is where the hormone-marker data lives, and also where the reported side effects such as water retention and raised appetite show up.