Peptide data sheet
Sermorelin
Performance · Sermorelin acetate · GRF 1-29 · Geref
Verdict
unprovenadult age-reversal / body-composition use
Quick answer
Sermorelin is a synthetic 29-amino-acid fragment of growth-hormone-releasing hormone (GHRH). It signals the pituitary to release its own growth hormone, and it was historically studied as a diagnostic agent and for childhood growth-hormone deficiency. The former prescription product, Geref, was discontinued from the US market, so sermorelin is not currently FDA-approved and is sold as a research chemical. The popular adult age-reversal and body-composition uses are not backed by large human trials.
- Class
- GHRH analog (GH secretagogue)
- Half-life
- Very short (minutes; estimated, not well characterized in current products)
- FDA status
- Not currently FDA-approved (former product Geref discontinued; sold as a research chemical)
- WADA banned?
- Yes
Which form actually works?
Injectable (subcutaneous)
Unproven
The form used in the older clinical literature and in compounding-pharmacy products; adult body-composition outcomes are not established in large human trials.
Oral / sublingual (marketed)
Risky
Sold online as drops or troches, but peptide absorption by these routes is poorly supported and product quality is unverified.