Peptide data sheet
Sermorelin
Performance · Sermorelin acetate · GRF 1-29 · Geref
Verdict
unprovenadult age-reversal / body-composition use
By MrPepTalks Editorial
Reviewed for scientific accuracy · research information, not medical advice
Last updated Reviewed
Quick answer
Sermorelin is a synthetic 29-amino-acid fragment of growth-hormone-releasing hormone (GHRH). It signals the pituitary to release its own growth hormone, and it was historically studied as a diagnostic agent and for childhood growth-hormone deficiency. The former prescription product, Geref, was discontinued from the US market, so sermorelin is not currently FDA-approved and is sold as a research chemical. The popular adult age-reversal and body-composition uses are not backed by large human trials.
- Class
- GHRH analog (GH secretagogue)
- Half-life
- Very short (minutes; estimated, not well characterized in current products)
- FDA status
- Not currently FDA-approved (former product Geref discontinued; sold as a research chemical)
- WADA banned?
- Yes
Which form actually works?
Injectable (subcutaneous)
Unproven
The form used in the older clinical literature and in compounding-pharmacy products; adult body-composition outcomes are not established in large human trials.
Oral / sublingual (marketed)
Risky
Sold online as drops or troches, but peptide absorption by these routes is poorly supported and product quality is unverified.
Third-Party Testing & Certificate of Analysis (COA)
A certificate of analysis (COA) is a lab document that reports what a specific batch of material actually contains. Reputable research suppliers publish one for every batch, tied to a lot number you can match against the vial you received.
- HPLC — purity
- High-performance liquid chromatography reports purity as a percentage: how much of the sample is the intended compound rather than impurities.
- Mass spectrometry (MS) — identity
- Mass spectrometry confirms identity by measuring the sample's molecular mass, so it matches the peptide the label names.
It also matters who ran the test. In-house results come from the seller's own lab; an independent third-party lab has no stake in the result, so its COA generally carries more weight. Look for a named testing laboratory, a batch or lot number, and a test date that lines up with the vial in hand.
New to reading one? This guide walks through a COA line by line: how to read a peptide COA.
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