Peptide data sheet
Mazdutide
GLP-1 · IBI362 · LY3305677
Verdict
promisingThe promising label reflects the published human trial data for weight and metabolic endpoints and a real regulatory approval in China; it is tempered by the fact that mazdutide is not FDA-approved in the United States, remains investigational there, and the research-grade material sold for lab use is not the reviewed pharmaceutical product.
By MrPepTalks Editorial
Reviewed for scientific accuracy · research information, not medical advice
Last updated Reviewed
Quick answer
Mazdutide (IBI362, LY3305677) is a peptide that acts on two metabolic receptors at once — the glucagon receptor and the GLP-1 receptor. It is most commonly researched for weight management and blood-sugar outcomes, and it has real human trial data behind it. China's regulator approved it for chronic weight management, but it is not FDA-approved in the United States; research-grade mazdutide sold for lab use is for laboratory research only.
- Class
- Dual agonist (glucagon / GLP-1 receptor)
- Half-life
- supports once-weekly research schedules (reported)
- FDA status
- Not FDA-approved in the United States. Mazdutide is approved by China's NMPA for chronic weight management but remains investigational in the U.S.; research-grade material sold for lab use is intended for laboratory research only.
- WADA banned?
- No
Which form actually works?
Injectable (subcutaneous)
Promising
The form used in the human trials and where essentially all of the research context lives. People report interest here because it matches how the compound was actually studied.
Oral
Unproven
Sometimes asked about by analogy to other metabolic drugs, but mazdutide's human data comes from the injectable form. An oral version is not where the studied evidence sits.
Third-Party Testing & Certificate of Analysis (COA)
A certificate of analysis (COA) is a lab document that reports what a specific batch of material actually contains. Reputable research suppliers publish one for every batch, tied to a lot number you can match against the vial you received.
- HPLC — purity
- High-performance liquid chromatography reports purity as a percentage: how much of the sample is the intended compound rather than impurities.
- Mass spectrometry (MS) — identity
- Mass spectrometry confirms identity by measuring the sample's molecular mass, so it matches the peptide the label names.
It also matters who ran the test. In-house results come from the seller's own lab; an independent third-party lab has no stake in the result, so its COA generally carries more weight. Look for a named testing laboratory, a batch or lot number, and a test date that lines up with the vial in hand.
New to reading one? This guide walks through a COA line by line: how to read a peptide COA.
Sources
- Ji L, Jiang H, Bi Y, et al. Mazdutide in Chinese adults with overweight or obesity (GLORY-1): a randomised, double-blind, placebo-controlled phase 3 trial. Reported clinical trial result.
- Ji L, Jiang H, Cheng Z, Qiu W, et al. A phase 2 randomised controlled trial of mazdutide in Chinese overweight adults or adults with obesity. Nat Commun. 2023;14(1):8289.
- Registered phase 3 study of mazdutide (IBI362) for weight management in Chinese adults with obesity (GLORY-2) — trial registry entry.
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